Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis

Lidia M Fernández-Sevilla; Germán Belenguer; Beatriz Martí-Prado; Paula Ortiz-Sánchez; Manuel Ramírez; Alberto Varas; Isabel Fariñas; Ángeles Vicente

doi:10.3324/haematol.2021.279383

Acute lymphoblastic leukemia cells are able to infiltrate the brain subventricular zone stem cell niche and impair neurogenesis

Haematologica. 2022 Apr 1;107(4):1004-1007. doi: 10.3324/haematol.2021.279383.

Authors

Lidia M Fernández-Sevilla¹, Germán Belenguer², Beatriz Martí-Prado², Paula Ortiz-Sánchez³, Manuel Ramírez⁴, Alberto Varas¹, Isabel Fariñas⁵, Ángeles Vicente⁶

Affiliations

¹ Department of Cell Biology, Faculty of Medicine, Complutense University, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
² CIBERNED, Departamento de Biología Celular, Biología Funcionaly Antropología Física, Instituto de Biotecnología y Biomedicina, Universitat de València, Valencia, Spain.
³ Department of Cell Biology, Faculty of Medicine, Complutense University, Madrid, Spain.
⁴ Department of Pediatric Hematology and Oncology, Advanced Therapies Unit, Niño Jesús University Children's Hospital, Madrid, Spain.
⁵ CIBERNED, Departamento de Biología Celular, Biología Funcionaly Antropología Física, Instituto de Biotecnología y Biomedicina, Universitat de València, Valencia, Spain. isabel.farinas@uv.es.
⁶ Department of Cell Biology, Faculty of Medicine, Complutense University, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. avicente@ucm.es.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain
Humans
Lateral Ventricles*
Neurogenesis
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Stem Cell Niche

Grants and funding

Funding: this work was supported by grants RTI2018-093899-BI00 and SAF2017-86690-R (Spanish Ministry of Economy and Competitiveness), RD16/0011/0002 and CB06/05/0086 (Institute of Health Carlos III, Spain), B2017/BMD-3692 AvanCell-CM (Community of Madrid), and Beca I-UnoEntreCienMil (Uno Entre Cien Mil Foundation). LMFS was supported by a pre doctoral fellowship (CT45/15 CT46/15) from the Complutense University of Madrid. POS is supported by a pre-doctoral fellowship (CT63/19- CT64/19) from the Complutense University.