Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly

Punnida Nonsuwan; Nanami Nishijima; Keita Sakakibara; Tadashi Nakaji-Hirabayashi; Chiaki Yoshikawa

doi:10.1039/d1tb02307a

Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly

J Mater Chem B. 2022 Apr 6;10(14):2444-2453. doi: 10.1039/d1tb02307a.

Authors

Punnida Nonsuwan¹, Nanami Nishijima^{1

2}, Keita Sakakibara³, Tadashi Nakaji-Hirabayashi^{1

2

4}, Chiaki Yoshikawa¹

Affiliations

¹ Research Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0047, Japan. yoshikawa.chiaki@nims.go.jp.
² Faculty of Engineering, Academic Assembly, University of Toyama, 3190 Gofuku, Toyama, Toyama 930-8555, Japan.
³ Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), 3-11-32 Kagamiyama, Higashi-hiroshima, Hiroshima 739-0046, Japan.
⁴ Graduate School of Innovative Life Science, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.

PMID: 35045146
DOI: 10.1039/d1tb02307a

Abstract

In order to develop new three-dimensional (3D) cell culture systems for articular cartilage regeneration, concentrated poly(styrene sulfonate sodium salt) brush-modified cellulose nanofibers were employed as building blocks for the self-assembly of human mesenchymal stem cells (hMSCs). Unique 3D cellular structures, such as giant spheres and sheets, were formed by controlling hMSC self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cellulose / pharmacology
Chondrogenesis
Humans
Mesenchymal Stem Cells*
Nanofibers* / chemistry
Polymers / pharmacology

Substances

Polymers
Cellulose