Sequence locally, think globally: The Darwin Tree of Life Project

Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2115642118. doi: 10.1073/pnas.2115642118.

Abstract

The goals of the Earth Biogenome Project-to sequence the genomes of all eukaryotic life on earth-are as daunting as they are ambitious. The Darwin Tree of Life Project was founded to demonstrate the credibility of these goals and to deliver at-scale genome sequences of unprecedented quality for a biogeographic region: the archipelago of islands that constitute Britain and Ireland. The Darwin Tree of Life Project is a collaboration between biodiversity organizations (museums, botanical gardens, and biodiversity institutes) and genomics institutes. Together, we have built a workflow that collects specimens from the field, robustly identifies them, performs sequencing, generates high-quality, curated assemblies, and releases these openly for the global community to use to build future science and conservation efforts.

Keywords: assembly; biodiversity; genome; sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biodiversity
  • Biological Evolution
  • Eukaryota / genetics*
  • Evolution, Molecular
  • Genome / genetics
  • Genomics / methods*
  • Phylogeny
  • Selection, Genetic / genetics
  • Sequence Analysis, DNA / methods
  • Specimen Handling / methods
  • Specimen Handling / standards
  • Workflow