A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients

Biyun Wang; Yannan Zhao; Yi Li; Yingying Xu; Yun Chen; Qiuyu Jiang; Dingjin Yao; Li Zhang; Xichun Hu; Chaowei Fu; Si Zhang; She Chen

doi:10.1186/s12943-022-01504-0

A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients

Mol Cancer. 2022 Jan 18;21(1):22. doi: 10.1186/s12943-022-01504-0.

Authors

Biyun Wang^#¹, Yannan Zhao^#^{1

2}, Yi Li^#^{1

2}, Yingying Xu^#², Yun Chen³, Qiuyu Jiang^{2

4}, Dingjin Yao², Li Zhang², Xichun Hu⁵, Chaowei Fu⁶, Si Zhang⁷, She Chen⁸

Affiliations

¹ Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, 270 Dong'an Road, Xuhui District, Shanghai, 200032, China.
² NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 130 Dong'an Road, Xuhui District, Shanghai, 200032, China.
³ School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China.
⁴ Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
⁵ Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, 270 Dong'an Road, Xuhui District, Shanghai, 200032, China. xchu2009@hotmail.com.
⁶ School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China. fcw@fudan.edu.cn.
⁷ NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 130 Dong'an Road, Xuhui District, Shanghai, 200032, China. zhangsi@fudan.edu.cn.
⁸ NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 130 Dong'an Road, Xuhui District, Shanghai, 200032, China. shechen@fudan.edu.cn.

^# Contributed equally.

No abstract available

Keywords: Breast cancer; Chemoresistance; MeCP2; Platinum; Prognostic biomarker; SNORD33.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / blood*
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
Prognosis
RNA, Small Nucleolar* / genetics
Triple Negative Breast Neoplasms / blood*
Triple Negative Breast Neoplasms / diagnosis*
Triple Negative Breast Neoplasms / drug therapy
Triple Negative Breast Neoplasms / etiology

Substances

Biomarkers, Tumor
RNA, Small Nucleolar

Associated data

ClinicalTrials.gov/NCT02546934
ClinicalTrials.gov/NCT02341911