The combination of photodynamic therapy and ultrapulse carbon dioxide laser for facial angiofibromas in tuberous sclerosis complex: A case report

Photodiagnosis Photodyn Ther. 2022 Mar:37:102725. doi: 10.1016/j.pdpdt.2022.102725. Epub 2022 Jan 15.

Abstract

Facial angiofibromas are one of the dermatological hallmarks of tuberous sclerosis complex. Facial angiofibromas often lead to disfigurement and cosmetic concerns, which has a serious negative effect on the quality of life of the patients. There are no guidelines or consensus on the management of facial angiofibromas up to now. We report a patient with extensive facial angiofibromas treated with the combination of photodynamic therapy and ultrapulse carbon dioxide laser, achieving satisfying results. We suggest this might be a promising therapeutic option for facial angiofibromas in tuberous sclerosis complex.

Keywords: Facial angiofibromas; Photodynamic therapy; Tuberous sclerosis complex; Ultrapulse carbon dioxide laser.

Publication types

  • Case Reports

MeSH terms

  • Angiofibroma* / complications
  • Angiofibroma* / drug therapy
  • Angiofibroma* / surgery
  • Facial Neoplasms* / complications
  • Facial Neoplasms* / drug therapy
  • Humans
  • Laser Therapy* / methods
  • Lasers, Gas* / therapeutic use
  • Photochemotherapy* / methods
  • Quality of Life
  • Tuberous Sclerosis* / complications
  • Tuberous Sclerosis* / therapy