Structural modeling was used to investigate presumed antecedents of hope in a community-based sample of Chinese adolescents. Specifically, we evaluated the mediating role of self-esteem in the link between social support from family and friends and individual differences in hope. The Multidimensional Scale of Perceived Social Support, Rosenberg Self-Esteem Scale, and Children's Hope Scale were administered to 1,654 adolescent students (781 boys and 873 girls) from Chinese senior high schools. Social support from family and friends correlated equally with hope levels of participants, demonstrating the importance of both sources of support. Self-esteem fully mediated the relationship between family support and hope and partially (23.6%) mediated the relationship between friends support and hope. Results support a social-cognitive model of the origins of hope among adolescents. Findings also suggest implications for the design of hope-promoting environments for adolescents that extend beyond a focus on the individual to incorporate more comprehensive systemic components, including social support from family and friends. [Journal of Psychosocial Nursing and Mental Health Services, 60(7), 39-46.].