Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis

Szimonetta Eitmann; Péter Mátrai; Dávid Németh; Péter Hegyi; Anita Lukács; Bálint Bérczi; László Márk Czumbel; István Kiss; Zoltán Gyöngyi; Gábor Varga; Márta Balaskó; Erika Pétervári

doi:10.1111/ppe.12859

Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis

Paediatr Perinat Epidemiol. 2022 Mar;36(2):276-287. doi: 10.1111/ppe.12859. Epub 2022 Jan 18.

Authors

Affiliations

¹ Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
² Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary.
³ Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
⁴ Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
⁵ Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
⁶ Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
⁷ Department of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.

Abstract

Background: Maternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.

Objectives: This systematic review and meta-analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.

Data sources: PubMed, EMBASE, Clinicaltrials.gov, CENTRAL.

Study selection and data extraction: Human studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.

Synthesis: Random-effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.

Results: After selection, 17 observational studies (140,517 mother-offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m² , 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m² , 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m² gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m² , 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m² , 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).

Conclusions: Independent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension.

Keywords: blood pressure; developmental programming; gestational weight gain; hypertension; maternal obesity.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Blood Pressure / physiology
Body Mass Index
Child
Female
Gestational Weight Gain*
Humans
Hypertension* / epidemiology
Hypertension* / etiology
Pediatric Obesity* / epidemiology
Pediatric Obesity* / etiology
Pregnancy