The present trial aimed to analyze the clinical efficacy of cooling blood detoxification decoction and nursing countermeasures in acute psoriasis from the perspective of immune function and inflammatory factors. Totally 120 patients with acute psoriasis presented to our hospital from January 2019 to January 2020 were randomized into group A and group B. Group B received routine treatment plus routine nursing, while group A received cooling blood detoxification decoction plus traditional Chinese medicine (TCM) care on the basis of the former group. Regarding the immune function indexes, the group A after treatment was superior to the group B; additionally, the inflammatory factors after treatment in group A was lower than group B; moreover, the PASI of group A at 6 weeks and 9 weeks after treatment was lower than group B; the QOL score of group A after treatment was superior to group B; the total number of effective treatment cases and nursing satisfaction were completely different when group A vs group B. Cooling blood detoxification decoction plus TCM nursing is a preferable technique for acute psoriasis to improve clinical symptoms, enhance immune function and diminish inflammatory factor levels, thereby optimizing the quality of life.