We consider the problem of distinguishing direct causes from direct effects of a target variable of interest from multiple manipulated datasets with unknown manipulated variables and nonidentical data distributions. Recent studies have shown that datasets attained from manipulated experiments (i.e., manipulated data) contain richer causal information than observational data for causal structure learning. Thus, in this article, we propose a new algorithm, which makes full use of the interventional properties of a causal model to discover the direct causes and direct effects of a target variable from multiple datasets with different manipulations. It is more suited to real-world cases and is also a challenge to be addressed in this article. First, we apply the backward framework to learn parents and children (PC) of a given target from multiple manipulated datasets. Second, we orient some edges connected to the target in advance through the assumption that the target variable is not manipulated and then orient the remaining undirected edges by finding invariant V-structures from multiple datasets. Third, we analyze the correctness of the proposed algorithm. To the best of our knowledge, the proposed algorithm is the first that can identify the local causal structure of a given target from multiple manipulated datasets with unknown manipulated variables. Experimental results on standard Bayesian networks validate the effectiveness of our algorithm.