Hyperspectral imagery with very high spectral resolution provides a new insight for subtle nuances identification of similar substances. However, hyperspectral target detection faces significant challenges of intraclass dissimilarity and interclass similarity due to the unavoidable interference caused by atmosphere, illumination, and sensor noise. In order to effectively alleviate these spectral inconsistencies, this paper proposes a novel target detection method without strict assumptions on data distribution based on an unconstrained linear mixture model and deep learning. Our proposed detector firstly reduces interference via a specifically designed deep-learning-based hierarchical denoising autoencoder, and then carries out accurate detection with a two-step subspace projection, aiming at background suppression and target enhancement. Additionally, to generate representative background and reliable target samples required in the detection procedure, an efficient spatial-spectral unified endmember extraction method has been developed. Performance comparison with several state-of-the-art detection methods and further analysis on four real-world hyperspectral images demonstrate the effectiveness and efficiency of our proposed target detector.