Redundant stations in the air quality monitoring network (AQMN), not only cause high maintenance and operation costs, but also affect the performance of air quality assessment. This study presents a novel framework for identifying the redundant stations and selecting the corresponding alternatives in AQMN. The framework composes three main steps. Firstly, we identify the redundant stations by correlation analysis and stepwise regression methods. Secondly, we determine the corresponding alternative stations by cluster analysis and correspondence analysis methods. Finally, the final optimization results are verified by the support vector regression. We perform empirical evaluations of the framework using Shanghai's AQMN. The results show that Xuhui, Zhangjiang, Shiwuchang, and Pudong New Area are four redundant pollution monitoring stations. Alternatives for each type of pollutant for these redundant stations are proposed and the adjusted layout of AQMN is verified with historical data. The framework proposed in this study can effectively improve the layout of AQMN, which could be applied to other cities or regions to improve the integrity of pollution information and reduce the monitoring costs.Implications: In this study, we set up a comprehensive framework. A case study proves that the framework we proposed can help countries identify redundant stations, so as to reduce the monitoring costs, improve the monitoring efficiency, and provide technical support for governments to implement accurate air quality control measures.Four particularly important aspects were highlighted in this work: (i) A new framework was constructed that combined regression and prediction for the first time to analyze and validate pollutant data; (ii) The framework used Stepwise Regression to improve previous methods for identifying redundant monitoring stations, effectively improving identification efficiency; (iii) The framework used Support Vector Regression to make predictions to verify the final results of the optimized layout, which was ignored in previous studies. (iv) This framework can be applied to any city or region, which has important practical significance for improving the comprehensiveness and accuracy of pollution monitoring in various cities.