Correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia

Sijing Duan; Yong Jiang; Kai Mou; Yi Wang; Shanshan Zhou; Bingxin Sun

Correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia

Am J Transl Res. 2021 Dec 15;13(12):14203-14210. eCollection 2021.

Authors

Sijing Duan¹, Yong Jiang², Kai Mou³, Yi Wang¹, Shanshan Zhou⁴, Bingxin Sun⁵

Affiliations

¹ Department of Obstetrics, Zibo First Hospital Zibo, Shandong Province, China.
² Department of Obstetrics, Zibo Maternal and Child Health Hospital Zibo, Shandong Province, China.
³ Department of Genetic Laboratory, Zibo Maternal and Child Health Hospital Zibo, Shandong Province, China.
⁴ Department of Pre-school Education, Zibo Normal College Zibo, Shandong Province, China.
⁵ Hospital Office, The Sixth People's Hospital of Zibo Zibo, Shandong Province, China.

PMID: 35035766
PMCID: PMC8748077

Abstract

Objective: To investigate the correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia.

Methods: The clinical data of 5,000 pregnant women in our hospital were retrospectively studied. Five hundred and sixty-five pregnant women with preeclampsia were divided into a mild group (259 cases) and a severe group (306 cases). The rest 4435 healthy pregnant women were classified as the healthy group. The concentrations of serum vitamin A and vitamin E in each group were compared to analyze the risk factors for preeclampsia.

Results: The levels of vitamin A and vitamin E were negatively correlated with the severity of preeclampsia (P<0.001). The logistic regression analysis showed that older age (OR=1.674), vitamin A deficiency (OR=2.463) and vitamin E deficiency (OR=2.206) were independent risk factors for preeclampsia (all P<0.05).

Conclusion: Older age, vitamin A deficiency and vitamin E deficiency are the risk factors for preeclampsia. The concentrations of vitamin A and vitamin E are negatively correlated with the severity of preeclampsia. Vitamin A and vitamin E deficiencies in preeclampsia can increase the risk of adverse pregnancy outcomes, which needs timely intervention.

Keywords: Vitamin A; correlation; preeclampsia; pregnancy outcome; pregnant woman; vitamin E.