Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases

Qinghong Chen; Junlin Fang; Hui Shen; Liping Chen; Mengying Shi; Xianbao Huang; Zhiwei Miao; Yating Gong

Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases

Am J Transl Res. 2021 Dec 15;13(12):13273-13297. eCollection 2021.

Authors

Qinghong Chen¹, Junlin Fang², Hui Shen³, Liping Chen³, Mengying Shi³, Xianbao Huang¹, Zhiwei Miao³, Yating Gong³

Affiliations

¹ Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine Nanchang 330006, Jiangxi, China.
² Department of Acupuncture and Moxibustion, Banan Hospital of Traditional Chinese Medicine Chongqing 401320, China.
³ Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou 215600, Jiangsu, China.

PMID: 35035675
PMCID: PMC8748174

Abstract

Transmembrane protein family members (TMEMs) span the entire lipid bilayer and act as channels that allow the transport of specific substances through biofilms. The functions of most TMEMs are unexplored. Numerous studies have shown that TMEMs are involved in the pathophysiological processes of various nervous system diseases, but the specific mechanisms of TMEMs in the pathogenesis of diseases remain unclear. In this review, we discuss the expression, physiological functions, and molecular mechanisms of TMEMs in brain tumors, psychiatric disorders, abnormal motor activity, cobblestone lissencephaly, neuropathic pain, traumatic brain injury, and other disorders of the nervous system. Additionally, we propose that TMEMs may be used as prognostic markers and potential therapeutic targets in patients with various neurological diseases.

Keywords: TMEMs; abnormal action; nervous system; psychiatric disorder; tumor.

Publication types

Review