A novel Ti-Au alloy with strong antibacterial properties and excellent biocompatibility for biomedical application

Shan Fu; Xiaotong Zhao; Lei Yang; Gaowu Qin; Erlin Zhang

doi:10.1016/j.msec.2022.112653

A novel Ti-Au alloy with strong antibacterial properties and excellent biocompatibility for biomedical application

Biomater Adv. 2022 Feb:133:112653. doi: 10.1016/j.msec.2022.112653. Epub 2022 Jan 10.

Authors

Shan Fu¹, Xiaotong Zhao¹, Lei Yang², Gaowu Qin², Erlin Zhang³

Affiliations

¹ Key Laboratory for Anisotropy and Texture of Materials (MoE), School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China.
² Key Laboratory for Anisotropy and Texture of Materials (MoE), School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China; Research Center for Metallic Wires, Northeastern University, Shenyang 110819, China.
³ Key Laboratory for Anisotropy and Texture of Materials (MoE), School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China; Research Center for Metallic Wires, Northeastern University, Shenyang 110819, China. Electronic address: zhangel@atm.neu.edu.cn.

PMID: 35034820
DOI: 10.1016/j.msec.2022.112653

Abstract

In order to avoid the toxic and side effects on human body of long-term dissolution of metal ions from antibacterial titanium alloys, Au element with non-toxicity and non-side effect was selected as the alloying element to prepare a new Ti-Au alloy with strong antibacterial property. We produced Ti-Au(S) sintered alloy by powder metallurgy and Ti-Au ingot alloy by ingot metallurgy, and investigated the influence of the secondary phase on the relative antimicrobial properties and antibacterial mechanism in this work. The results indicated that the aged Ti-Au(T6) alloy and Ti-Au(S) sintered alloy exhibited strong antibacterial rate against S. aureus due to the formation of Ti₃Au phases. In vitro cell culture (MC3T3 cells) experiments showed that Ti-Au alloys had good cytocompatibility and osteogenic properties. The following viewpoints of antibacterial mechanism are that the Ti₃Au destroyed the ROS homeostasis of bacteria, causing oxidative stress in bacterial cells and preventing from the biofilms formation.

Keywords: Antibacterial property; Cell compatibility; Existing form of precipitate; Osteogenesis properties; Ti-Au alloy.

MeSH terms

Aged
Alloys* / pharmacology
Anti-Bacterial Agents / pharmacology
Corrosion
Humans
Staphylococcus aureus*
Titanium / pharmacology

Substances

Alloys
Anti-Bacterial Agents
Titanium