Daldinans D‒G, new isoindolinone antioxidants isolated from the ascomycete Daldinia concentrica

Dae-Won Ki; Seong-Eun Kim; Ji-Yul Kim; Ja-Gyeong Song; Byung Soon Hwang; In-Kyoung Lee; Bong-Sik Yun

doi:10.1007/s11418-021-01592-0

Daldinans D‒G, new isoindolinone antioxidants isolated from the ascomycete Daldinia concentrica

J Nat Med. 2022 Mar;76(2):476-481. doi: 10.1007/s11418-021-01592-0. Epub 2022 Jan 16.

Authors

Dae-Won Ki^#¹, Seong-Eun Kim^#¹, Ji-Yul Kim^{1

2}, Ja-Gyeong Song^{1

3}, Byung Soon Hwang^{1

4}, In-Kyoung Lee¹, Bong-Sik Yun⁵

Affiliations

¹ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, South Korea.
² National Marine Biodiversity Institute of Korea, Janghang-eup, South Korea.
³ Korea Research Institute of Bioscience and Biotechnology, Ochang, South Korea.
⁴ The Food Industry Promotional Agency of Korea, Iksan, South Korea.
⁵ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, South Korea. bsyun@jbnu.ac.kr.

^# Contributed equally.

PMID: 35034277
DOI: 10.1007/s11418-021-01592-0

Abstract

Four new isoindolinone derivatives, daldinans D‒G (3‒6), together with two known compounds, daldinans A and B (1 and 2), were isolated from the stroma of the ascomycete Daldinia concentrica. Chemical structures of the isolated compounds were determined by spectroscopic methods. All of these compounds exhibited antioxidant activities with IC₅₀ values of 3.21 to 39.67 µM in the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay.

Keywords: Antioxidant; Daldinan; Daldinia concentrica; Isoindolinone derivatives; Mushroom.

MeSH terms

Antioxidants* / chemistry
Ascomycota* / chemistry
Phthalimides

Substances

Antioxidants
Phthalimides
phthalimidine

Supplementary concepts

Daldinia concentrica