Simultaneous spectrophotometric determination of drug components from their dosage formulations

Abstract

Spectrophotometry is a quick and reliable method for determining the composition of a variety of complex drug mixtures. Several mathematical models are available for the resolution of complex multicomponent UV spectra. UV spectrophotometric methods have the inherent capacity to resolve the interlaced spectra of complex mixtures quickly and appropriately, particularly for quantitative determination of components of mixture where several costly tools are not available. These methods also have the benefit of lower operational costs as they are operated using lesser amounts of analytical grade solvents and generate less waste. In this review, we discussed the theoretical background of different UV spectrometric methods for quantitative analysis of drug mixtures. The main focus of this review is to describe and report applications of extended Beer's law-based multicomponent analysis and to highlight the recent developments in the simultaneous determination of drug components from their complex mixtures.

Keywords: Dosage forms; Drugs; Multicomponent analysis; Pharmaceutical compounds; Simultaneous determination; Spectrophotometry.