Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols

Monica Bucciantini; Manuela Leri; Maria Scuto; Marialaura Ontario; Angela Trovato Salinaro; Edward J Calabrese; Vittorio Calabrese; Massimo Stefani

doi:10.1016/j.mad.2022.111620

Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols

Mech Ageing Dev. 2022 Mar:202:111620. doi: 10.1016/j.mad.2022.111620. Epub 2022 Jan 13.

Authors

Monica Bucciantini¹, Manuela Leri², Maria Scuto³, Marialaura Ontario⁴, Angela Trovato Salinaro⁵, Edward J Calabrese⁶, Vittorio Calabrese⁷, Massimo Stefani⁸

Affiliations

¹ Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy. Electronic address: monica.bucciantini@unifi.it.
² Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy. Electronic address: manuela.leri@unifi.it.
³ Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy. Electronic address: mary-amir@hotmail.it.
⁴ Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy. Electronic address: marialaura.ontario@ontariosrl.it.
⁵ Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy. Electronic address: trovato@unict.it.
⁶ Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
⁷ Department of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy. Electronic address: calabres@unict.it.
⁸ Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy. Electronic address: massimo.stefani@unifi.it.

PMID: 35033546
DOI: 10.1016/j.mad.2022.111620

Abstract

The paper provides a comprehensive and foundational mechanistic framework of hormesis that establishes its centrality in medicine and public health. This hormetic framework is applied to the assessment of olive polyphenols with respect to their capacity to slow the onset and reduce the magnitude of a wide range of age-related disorders and neurodegenerative diseases, including Alzheimer's Disease and Parkinson's Disease. It is proposed that olive polyphenol-induced anti-inflammatory protective effects are mediated in large part via the activation of AMPK and the upregulation of Nrf2 pathway. Consistently, herein we also review the importance of the modulation of Nrf2-related stress responsive vitagenes by olive polyphenols, which at low concentration according to the hormesis theory activates this neuroprotective cascade to preserve brain health and its potential use in the prevention and therapy against aging and age-related cognitive disorders in humans.

Keywords: Lifespan; Neurodegeneration; Olive oil polyphenols; Vitagenes; Xenohormesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / metabolism
Hormesis
Humans
Neurodegenerative Diseases* / prevention & control
Olea*
Polyphenols / pharmacology

Substances

Polyphenols