The Diagnostic Accuracy of Xpert Xpress to SARS-CoV-2: A systematic review

Xun-Jie Cao; Ke-Ying Fang; Ya-Ping Li; Jie Zhou; Xu-Guang Guo

doi:10.1016/j.jviromet.2022.114460

The Diagnostic Accuracy of Xpert Xpress to SARS-CoV-2: A systematic review

J Virol Methods. 2022 Mar:301:114460. doi: 10.1016/j.jviromet.2022.114460. Epub 2022 Jan 12.

Authors

Xun-Jie Cao¹, Ke-Ying Fang¹, Ya-Ping Li², Jie Zhou¹, Xu-Guang Guo³

Affiliations

¹ Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China; Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 510150, China.
² Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China; Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 510150, China; Department of Clinical Medicine, The Second Clinical School of Guangzhou Medical University, Guangzhou, 510150, China.
³ Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China; Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 510150, China; Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Clinical School of Guangzhou Medical University, Guangzhou, 510150, China; Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Clinical School of Guangzhou Medical University, Guangzhou, 510150, China. Electronic address: gysygxg@gmail.com.

Abstract

The SARS-CoV-2 infection rate, as well as mortality rate, is high. There is an urgent need for a high-throughput, accurate and reliable method of diagnosing COVID-19 pneumonia. We included references from databases, such as PubMed, Cochrane Library, Web of Science, and Embase, and extracted data. Then, MetaDisc and STATA were used to establish forest plots and funnel plots for meta-analysis. We collected 14 articles and performed a systematic review. The following results were obtained: sensitivity and specificity were 0.97 (0.96 to 0.98) and 0.97 (0.96 to 0.98) respectively; PLR and NLR were 24.51 (16.63-36.12) and 0.03 (0.01 to 0.10) respectively, DOR was 975.15 (430.11-2210.88), and AUC was 0.9926. When Xpress detects SARS-CoV-2 in different samples, the heterogeneity is small and the specificity and sensitivity are extremely high. We recommend the employment of Xpert Xpress analysis in rapid screening.

Keywords: COVID-19 pneumonia; Diagnostic accuracy; SARS-CoV-2; Systemic review; Xpert Xpress.

Publication types

Systematic Review

MeSH terms

COVID-19 Testing
COVID-19*
Humans
Molecular Diagnostic Techniques / methods
SARS-CoV-2*
Sensitivity and Specificity