Ubiquitination regulation of aerobic glycolysis in cancer

Yao Xie; Mu Wang; Min Xia; Yinping Guo; Xuyu Zu; Jing Zhong

doi:10.1016/j.lfs.2022.120322

Ubiquitination regulation of aerobic glycolysis in cancer

Life Sci. 2022 Mar 1:292:120322. doi: 10.1016/j.lfs.2022.120322. Epub 2022 Jan 11.

Authors

Yao Xie¹, Mu Wang², Min Xia³, Yinping Guo³, Xuyu Zu⁴, Jing Zhong⁵

Affiliations

¹ Institute of Clinical Medicine, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China; Department of Clinical Laboratory, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.
² Clinical Research Institute, the NanHua Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.
³ Institute of Clinical Medicine, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China.
⁴ Institute of Clinical Medicine, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China; Cancer Research Institute, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: zuxuyu0108@hotmail.com.
⁵ Institute of Clinical Medicine, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China; Cancer Research Institute, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: zhongjing2002@usc.edu.cn.

PMID: 35031261
DOI: 10.1016/j.lfs.2022.120322

Abstract

Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic reprogramming and plays a crucial role in the occurrence and development of tumours. Ubiquitination and deubiquitination, essential post-translational modifications, have attracted increasing attention with regards to the regulation of metabolic reprogramming in cancer. However, the mechanism of ubiquitination in glycolysis remains unclear. In this review, we discuss the roles of ubiquitination and deubiquitination in regulating glycolysis, and their involvement in regulating important signalling pathways, enzymes, and transcription factors. Focusing on potential mechanisms may provide novel strategies for cancer treatment.

Keywords: Aerobic glycolysis; Cancer; Deubiquitination; Metabolic reprogramming; Ubiquitination.

Publication types

Review

MeSH terms

Glycolysis*
Humans
Neoplasms / metabolism*
Ubiquitination*