Exploring Anticancer and (Bio)catalytic Activities of New Oxovanadium(V), Dioxomolybdenum(VI), and Copper(II) Complexes of Amide-Imine Conjugates

Sabyasachi Ta; Milan Ghosh; Kajari Ghosh; Paula Brandão; Vítor Félix; Sumit Kumar Hira; Partha Pratim Manna; Debasis Das

doi:10.1021/acsabm.9b00226

Exploring Anticancer and (Bio)catalytic Activities of New Oxovanadium(V), Dioxomolybdenum(VI), and Copper(II) Complexes of Amide-Imine Conjugates

ACS Appl Bio Mater. 2019 Jul 15;2(7):2802-2811. doi: 10.1021/acsabm.9b00226. Epub 2019 Jun 20.

Authors

Sabyasachi Ta, Milan Ghosh, Kajari Ghosh, Paula Brandão¹, Vítor Félix¹, Sumit Kumar Hira, Partha Pratim Manna², Debasis Das

Affiliations

¹ Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.
² Department of Zoology, Banaras Hindu University, Varanasi, India.

PMID: 35030814
DOI: 10.1021/acsabm.9b00226

Abstract

An amide-imine conjugate, (E)-N'-((2-hydroxynaphthalen-1-yl) methylene)-4-methylbenzohydrazide (PTANAP), derived from 4-methyl-benzoic acid hydrazide (PTA) and 2-hydroxynapthaldehyde, is explored to prepare dinuclear oxovanadium(V), mononuclear dioxomolydenum(VI), and Cu(II) complexes. Single crystal X-ray structurally characterized complexes have been exploited as catalyst for oxidation of ethylbenzene, catechol, and o-aminophenol. The anticancer properties of the oxo-vanadium complex have been explored against human leukemia cell (K-562) and mouse lymphoma cells (2PK3).

Keywords: (bio)catalysis; Cu(II) complex; amide−imine conjugate; anticancer activity; dioxomolybdenum; oxovanadium(V).