Analysis of the nystagmus characteristics of cupula diseases: A case report

Medicine (Baltimore). 2022 Jan 7;101(1):e28211. doi: 10.1097/MD.0000000000028211.

Abstract

Introduction: Clinically, there is a kind of patients with positional vertigo or dizziness, which occurs when they turn left or right, look down or up, lie down or sit up. With a long duration and varying frequency, it is not consistent with the manifestations of benign paroxysmal positional vertigo (BPPV). In addition, the persistent geotropic direction-changing positional nystagmus (PG-DCPN) was observed in a supine head-roll test.

Patient concerns: With no apparent trigger for visual rotation and a sense of self instability, an 81-year-old female patient had suffered from vertigo for 3 days. The vertigo occurred every day, lasting several minutes each time, and associated with head movements and changes in body position. In a supine head-roll test, it appeared persistent geotropic direction-changing positional nystagmus for a long time, without latency, fatigability and in the presence of 3 zero planes.

Diagnosis: Light cupula.

Interventions: Difenidol hydrochloride 25 mg orally 3 times/day for 2 weeks and betahistine hydrochloride 12 mg orally 3 times/day for 1 month were administered.

Outcomes: After 1 month of treatment, the patient's vertigo symptoms disappeared. And in the supine head-roll test, the persistent geotropic direction-changing positional nystagmus disappeared.

Conclusion: We report the characteristics of nystagmus produced in a typical patient with light cupula during the supine head-roll test. After reviewing the relevant literatures, we believe that a simpler method can be used to identify canalolithiasis and cupula disease, to distinguish light and heavy cupula, and to determine the pathological semicircular canal to which the lesion belongs.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Betahistine / administration & dosage
  • Betahistine / therapeutic use
  • Female
  • Humans
  • Nystagmus, Pathologic / diagnosis*
  • Nystagmus, Pathologic / drug therapy
  • Nystagmus, Physiologic
  • Piperidines / administration & dosage
  • Piperidines / therapeutic use
  • Supine Position*
  • Vestibular Function Tests

Substances

  • Piperidines
  • diphenidol
  • Betahistine