Klebsiella pneumoniae-related brain abscess and meningitis in adults: Case report

Medicine (Baltimore). 2022 Jan 14;101(2):e28415. doi: 10.1097/MD.0000000000028415.

Abstract

Introduction: Klebsiella pneumoniae is once thought to be a less common cause of brain abscess in adults and is mainly hospital-acquired. Community-acquired CNS infection (brain abscess and meningitis) caused by K pneumoniae without other metastatic septic abscesses is exceedingly rare. Therefore, we present a rare adult patient with invasive cerebral abscess and meningitis without other invasive abscesses related to K pneumoniae.

Patient concerns: A 64-year-old woman experienced a sudden onset of severe continuous headache accompanied by intermittent nausea, vomiting, and fever. Meanwhile, she experienced tinnitus and had a feeling of swelling in the right ear.

Diagnosis: Cranial magnetic resonance imaging revealed abnormal hyperintensity signals in the left head of the caudate nucleus. The next generation sequencing of cerebral spinal fluid showed infection with K pneumoniae. The patient was diagnosed with K pneumoniae-related brain abscesses and meningitis.

Interventions: Antibacterial treatment was carried out for 2 months.

Outcomes: The patient recovered well.

Conclusion: Despite the progress of modern neurosurgical techniques, new antibiotics, and modern imaging techniques, brain abscesses are still a potentially fatal infection. Streptococci are common organisms that result in brain abscesses. Nevertheless, Klebsiella species, once thought to be a less common cause of brain abscess in adults, has become an increasingly important cause of brain abscess, especially in Asia.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Brain Abscess* / diagnostic imaging
  • Brain Abscess* / drug therapy
  • Brain Abscess* / microbiology
  • Community-Acquired Infections* / drug therapy
  • Community-Acquired Infections* / microbiology
  • Female
  • Humans
  • Klebsiella Infections* / complications
  • Klebsiella Infections* / diagnosis
  • Klebsiella Infections* / drug therapy
  • Klebsiella pneumoniae
  • Meningitis* / drug therapy
  • Meningitis* / microbiology
  • Middle Aged

Substances

  • Anti-Bacterial Agents