Keywords: 1929 (corresponding to main clade II in the trees) is re-introduced. Siciliariascarificata did not appear in one of the two main clades but clustered together with Mauritanicaperinnipolygyra. Concerning monophyly of species; 26 specimens of 14 taxa of five genera (MolluscaBase 2021) of Alopiinae (Mauritanica; Charpentieria; Clausiliidae; Gibbularia; Papillifera) were included in the genetic analyses. New anatomical structures are described: the parapseudopapilla for Charpentieriadyodon and the hemipapilla for Charpentieriastenzii. In the phylogenetic tree based on COI sequences; Siciliaria; Siciliariacalcaraecruentassp. nov.; Siciliariacalcaraejatinensisssp. nov., Siciliariacalcaraeparajatinensisssp. nov.; Stigmatica; The taxonomy and systematics of the door snail genus Siciliaria was revised based on an integrative approach including a comprehensive genital anatomical investigation; a finding that has to be investigated further with multiple marker sequences. For the other genera (Mauritanica; and Papillifera) detailed descriptions of the anatomy of the genital organs of 46 taxa for a total amount of 133 dissected specimens are also provided here. Some of these taxa could be included in the phylogenetic analysis. Although the taxon sampling of these taxa was far from being complete; and Siciliariatiberiiarmettensisssp. nov. Anatomy of genital organs; and a new general description of the genital morphology of the genus is provided. Additionally; and distribution) provide first insights into the phylogenetic relationships of this diverse group of clausiliid taxa. The following six taxa new to science are described: Siciliariagrohmannianaaddauraessp. nov., Siciliariacalcaraeborgettensisssp. nov.; genetics; nuclear ITS2 sequences). The genital morphology of 120 specimens of 22 taxa from 44 populations was investigated; only the widely distributed S.calcarae was paraphyletic in the COI tree; phylogeny; resolution was considerably lower but it partially confirmed the mitochondrial tree. The genus Sicania Tomlin; systematics; taxonomy; the comprehensive data provided here (concerning morphology; the species of the genus Siciliaria s. l. from northwestern Sicily were found within two separate highly supported main clades. In the tree based on the nuclear ITS2 marker sequence; which was combined with shell morphology and DNA sequence data (mitochondrial COI.