En garde! The duel functions of MORC3

Lindsey E Fox; Deborah J Lenschow

doi:10.1016/j.chom.2021.12.017

En garde! The duel functions of MORC3

Cell Host Microbe. 2022 Jan 12;30(1):8-9. doi: 10.1016/j.chom.2021.12.017.

Authors

Lindsey E Fox¹, Deborah J Lenschow²

Affiliations

¹ Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
² Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: dlenschow@wustl.edu.

PMID: 35026136
DOI: 10.1016/j.chom.2021.12.017

Abstract

Effector-triggered immunity involves "guarded" host processes that, when perturbed by pathogen factors, prompt a secondary response. A recent study published in Nature by Gaidt et al. demonstrates that MORC3 serves as both the guard and the guarded antiviral host factor-creating a "heads, I win; tails, you lose!" scenario.

MeSH terms

Adenosine Triphosphatases / genetics
Adenosine Triphosphatases / metabolism*
Antiviral Agents
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Host Microbial Interactions / immunology
Humans
Ubiquitin-Protein Ligases
Virulence Factors / immunology

Substances

Antiviral Agents
DNA-Binding Proteins
Virulence Factors
Ubiquitin-Protein Ligases
Adenosine Triphosphatases
MORC3 protein, human