Dietary Phytochemicals that Can Extend Longevity by Regulation of Metabolism

Plant Foods Hum Nutr. 2022 Mar;77(1):12-19. doi: 10.1007/s11130-021-00946-z. Epub 2022 Jan 13.

Abstract

Diet provides energy and nutrition for human survival, and also provides various joy of taste. Extensive studies have shown that the major components of diet, such as protein, carbohydrate and fat, play important roles in regulating aging and longevity. Whether other dietary ingredients can help prevent aging and extend longevity is a very interesting question. Here based on recent findings, we discussed dietary plant ingredients that can extend longevity by regulation of metabolism, targeting TRP channels, mitophagy, senescence pathways and circadian rhythms. Better understanding of the detailed effects and mechanisms of dietary ingredients on longevity regulation, would be helpful for developing new intervention tools for preventing aging and aging related diseases.

Keywords: Aging; Capsaicin; Fisetin; Metabolism; Nobiletin; Phytochemical; Urolithin a.

Publication types

  • Review

MeSH terms

  • Diet
  • Longevity* / physiology
  • Phytochemicals* / pharmacology

Substances

  • Phytochemicals