First-Line Anlotinib Combined with Stereotactic Body Radiation Therapy for an Octogenarian with Pulmonary Carcinosarcoma

Long Liang; Taiyu Chen; Tao Ren; Mian Mao; Keli Wang; Chunhan Tang; Juan Xiao; Hongyuan Jia; Wenli Chen; Qifeng Wang; Tao Li

doi:10.2147/CMAR.S344149

First-Line Anlotinib Combined with Stereotactic Body Radiation Therapy for an Octogenarian with Pulmonary Carcinosarcoma

Cancer Manag Res. 2022 Jan 6:14:103-106. doi: 10.2147/CMAR.S344149. eCollection 2022.

Authors

Long Liang^#¹, Taiyu Chen^#², Tao Ren³, Mian Mao⁴, Keli Wang⁵, Chunhan Tang², Juan Xiao¹, Hongyuan Jia¹, Wenli Chen¹, Qifeng Wang¹, Tao Li¹

Affiliations

¹ Department of Radiation Oncology, Sichuan Cancer Hospital and Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.
² Clinical Medical College of Chengdu Medical College, Chengdu, 610500, People's Republic of China.
³ Oncology Department, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, People's Republic of China.
⁴ Department of Pharmacy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
⁵ Clinical Medical College of Southwest Medical University, Luzhou, 646000, People's Republic of China.

^# Contributed equally.

Abstract

Pulmonary carcinosarcoma (PC) is a rare and highly malignant type of non-small cell lung cancer (NSCLC) that is insensitive to radiotherapy and chemotherapy and has a poor prognosis. Here, we report a case of an 88-year-old patient with inoperable PC and a history of cerebral infarction who was treated with first-line anlotinib combined with stereotactic body radiation therapy (SBRT). The therapeutic response has sustained for 10 months. Our work suggests that SBRT combined with anlotinib may be a safe and effective treatment strategy for octogenarians with PC.

Keywords: SBRT; anlotini; pulmonary carcinosarcoma.

Publication types

Case Reports