Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

Chao-Yue Cui; Qiwei Chen; Qian He; Chong Chen; Rong-Min Zhang; Youjun Feng; Jian Sun

doi:10.1002/wsbm.1538

Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

WIREs Mech Dis. 2022 Jan;14(1):e1538. doi: 10.1002/wsbm.1538. Epub 2021 Oct 5.

Authors

Chao-Yue Cui^{1

2

3}, Qiwei Chen^{4

5}, Qian He^{1

2

3}, Chong Chen⁶, Rong-Min Zhang^{1

2

3}, Youjun Feng^{2

5

7}, Jian Sun^{1

2

3}

Affiliations

¹ National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
² Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, China.
³ Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
⁴ State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
⁵ Department of Microbiology, and Department of General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
⁶ Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, Jiangsu, China.
⁷ College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

PMID: 35023325
DOI: 10.1002/wsbm.1538

Abstract

Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology.

Keywords: Tet(X); tetracycline; tigecycline resistance; transferability.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents* / pharmacology
Microbial Sensitivity Tests
Tetracycline
Tetracycline Resistance* / genetics
Tigecycline

Substances

Anti-Bacterial Agents
Tigecycline
Tetracycline