Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery

Wen-Bin Liu; Shu-Ming Kang; Xun-Hui Xu; Li Zhou; Na Liu; Zong-Quan Wu

doi:10.1021/acsabm.0c00523

Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H₂O₂/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery

ACS Appl Bio Mater. 2020 Sep 21;3(9):5620-5626. doi: 10.1021/acsabm.0c00523. Epub 2020 Aug 11.

Authors

Wen-Bin Liu¹, Shu-Ming Kang¹, Xun-Hui Xu¹, Li Zhou¹, Na Liu¹, Zong-Quan Wu¹

Affiliation

¹ Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, and Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, China.

PMID: 35021793
DOI: 10.1021/acsabm.0c00523

Abstract

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H₂O₂. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

Keywords: doxorubicin; dual stimuli-responsiveness; helical structure; high capacity; shell cross-linked nanoparticles.