Preparation and Properties of Polydimethylsiloxane (PDMS)/Polyethylene Glycol (PEG)-Based Amphiphilic Polyurethane Elastomers

Yinlei Lin; Deliu He; Huawen Hu; Peng Yi; Xiaoting Liu; Jianhui Huang; Shaozhen Wu; Guangji Li

doi:10.1021/acsabm.9b00605

Preparation and Properties of Polydimethylsiloxane (PDMS)/Polyethylene Glycol (PEG)-Based Amphiphilic Polyurethane Elastomers

ACS Appl Bio Mater. 2019 Oct 21;2(10):4377-4384. doi: 10.1021/acsabm.9b00605. Epub 2019 Oct 9.

Authors

Yinlei Lin^{1

2}, Deliu He², Huawen Hu¹, Peng Yi², Xiaoting Liu¹, Jianhui Huang¹, Shaozhen Wu¹, Guangji Li²

Affiliations

¹ School of Materials Science and Energy Engineering, Foshan University, No. 18 Jiangwan First Road, Changcheng District, Foshan, Guangdong 528000, China.
² School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Tianhe District, Guangzhou, Guangdong 510640, China.

PMID: 35021397
DOI: 10.1021/acsabm.9b00605

Abstract

Amphiphilic polyurethane elastomers (APUE) were synthesized using a two-step polyaddition reaction based on the hydroxyl-terminated polydimethylsiloxane (PDMS) and polyethylene glycol (PEG) soft segments with the molecular weights (M_w's) of 2000 and 1000, respectively. The effects of the PDMS/PEG contents on the properties and structures of the APUE were investigated. It was found that the APUE possessed high elongation, moderate tensile strength, and good thermal properties. In addition, the APUE showed tunable oxygen permeability (Dk) and water vapor transmission rate (WVTR), and a similar WVTR to that of skin could be obtained for the optimized sample (APUE2). Importantly, APUE also exhibited excellent antibacterial efficacy against two kinds of bacteria along with impressive cytocompatibility. All of the results demonstrated that the synthesized APUE will hold substantial potential for biomaterial applications.

Keywords: amphiphilic surface; multiblock copolymer; polyaddition reaction; polydimethylsiloxane; polyethylene glycol; polyurethane elastomers.