Goldilocks and the three TILs

Hannah Dada; Michael L Dustin

doi:10.1084/jem.20212269

Goldilocks and the three TILs

J Exp Med. 2022 Feb 7;219(2):e20212269. doi: 10.1084/jem.20212269. Epub 2022 Jan 12.

Authors

Hannah Dada¹, Michael L Dustin²

Affiliations

¹ National lnstitutes of Health Oxford-Cambridge Scholars Program, Center for Cancer Research, National Cancer Institute, National lnstitutes of Health, Bethesda, MD.
² Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

Abstract

In this issue of JEM, Shakiba et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201966) tell a tale of three tumor infiltrating lymphocytes (TILs). The first TIL was too strong and became exhausted. The second TIL was too weak and became inert. The third TIL lost CD8, and this made it just right.

Publication types

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MeSH terms

Lymphocytes, Tumor-Infiltrating*