Thermometer: a webserver to predict protein thermal stability

Mattia Miotto; Alexandros Armaos; Lorenzo Di Rienzo; Giancarlo Ruocco; Edoardo Milanetti; Gian Gaetano Tartaglia

doi:10.1093/bioinformatics/btab868

Thermometer: a webserver to predict protein thermal stability

Bioinformatics. 2022 Mar 28;38(7):2060-2061. doi: 10.1093/bioinformatics/btab868.

Authors

Mattia Miotto^{1

2}, Alexandros Armaos³, Lorenzo Di Rienzo², Giancarlo Ruocco^{1

2}, Edoardo Milanetti^{1

2}, Gian Gaetano Tartaglia^{2

3}

Affiliations

¹ Department of Physics, Sapienza University of Rome, 00185 Rome, Italy.
² Center for Life Nano & Neuroscience, Italian Institute of Technology, 00161 Rome, Italy.
³ Department of Biology, Sapienza University of Rome, 00185 Rome, Italy.

Abstract

Motivation: Thermal properties of proteins are of great importance for a number of theoretical and practical implications. Predicting the thermal stability of a protein is a difficult and still scarcely addressed task.

Results: Here, we introduce Thermometer, a webserver to assess the thermal stability of a protein using structural information. Thermometer is implemented as a publicly available, user-friendly interface.

Availability and implementation: Our server can be found at the following link (all major browser supported): http://service.tartaglialab.com/new_submission/thermometer_file.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computers
Protein Stability
Proteins
Software*
Thermometers*

Substances

Proteins