3D Biofabrication Using Living Cells for Applications in Biohybrid Sensors and Actuators

Minghao Nie; Shoji Takeuchi

doi:10.1021/acsabm.0c01214

3D Biofabrication Using Living Cells for Applications in Biohybrid Sensors and Actuators

ACS Appl Bio Mater. 2020 Dec 21;3(12):8121-8126. doi: 10.1021/acsabm.0c01214. Epub 2020 Nov 19.

Authors

Minghao Nie¹, Shoji Takeuchi^{1

2

3

4}

Affiliations

¹ Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo 113-8656, Japan.
² Institute of Industrial Science (IIS), The University of Tokyo, Tokyo 153-8505, Japan.
³ International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo 113-0033, Japan.
⁴ Artificial Cell Membrane Systems Group, Kanagawa Institute of Industrial Science and Technology, Kanagawa 213-0012, Japan.

PMID: 35019594
DOI: 10.1021/acsabm.0c01214

Abstract

In this paper, we highlight the concept of biohybrid sensors and actuators built by incorporating living cells into artificial systems. Instead of using the materials extracted from cells, these approaches utilize cells to dynamically generate functional materials and to provide the native intracellular environment for the proper functioning of the materials. By incorporating the functional cells into artificial devices/chips, the cell-based biohybrid approaches can be applied to create portable odorant sensors with high sensitivity and to create biohybrid muscle actuators for applications in both drug screening and soft robotics.

Keywords: biofabrication; biohybrid systems; biosensors; cell-based sensors and actuators; microfabrication; tissue engineering.