Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease

Ivan Martinez-Valbuena; Naomi P Visanji; Diana A Olszewska; Mario Sousa; Puja Bhakta; Anna Vasilevskaya; Chloe Anastassiadis; Maria Carmela Tartaglia; Gabor G Kovacs; Anthony E Lang

doi:10.1002/mds.28912

Combining Skin α-Synuclein Real-Time Quaking-Induced Conversion and Circulating Neurofilament Light Chain to Distinguish Multiple System Atrophy and Parkinson's Disease

Mov Disord. 2022 Mar;37(3):648-650. doi: 10.1002/mds.28912. Epub 2022 Jan 12.

Authors

Ivan Martinez-Valbuena¹, Naomi P Visanji^{2

3

4}, Diana A Olszewska², Mario Sousa², Puja Bhakta², Anna Vasilevskaya¹, Chloe Anastassiadis¹, Maria Carmela Tartaglia^{1

4

5

6}, Gabor G Kovacs^{1

2

3

4

7}, Anthony E Lang^{1

2

4

5

6}

Affiliations

¹ Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
² Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.
³ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
⁴ Krembil Brain Institute, Toronto, Ontario, Canada.
⁵ Department of Medicine, University Health Network, Toronto, Ontario, Canada.
⁶ Department of Neurology, University Health Network, Toronto, Ontario, Canada.
⁷ Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

PMID: 35019153
DOI: 10.1002/mds.28912

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Humans
Intermediate Filaments
Multiple System Atrophy* / diagnosis
Parkinson Disease* / diagnosis
Skin
alpha-Synuclein

Substances

Biomarkers
alpha-Synuclein