Dolabellane Diterpenes and Elemane Alkaloids from the Soft Coral Clavularia inflata Collected in the South China Sea

Xiao Han; Xiangchao Luo; Lei Xue; Leen van Ofwegen; Wenjie Zhang; Kechun Liu; Yun Zhang; Xuli Tang; Pinglin Li; Guoqiang Li

doi:10.1021/acs.jnatprod.1c01103

Dolabellane Diterpenes and Elemane Alkaloids from the Soft Coral Clavularia inflata Collected in the South China Sea

J Nat Prod. 2022 Jan 28;85(1):276-283. doi: 10.1021/acs.jnatprod.1c01103. Epub 2022 Jan 12.

Authors

Xiao Han^{1

2}, Xiangchao Luo^{1

2}, Lei Xue^{1

2}, Leen van Ofwegen³, Wenjie Zhang^{1

2}, Kechun Liu⁴, Yun Zhang⁴, Xuli Tang⁵, Pinglin Li^{1

2}, Guoqiang Li^{1

2}

Affiliations

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
² Laboratory of Marine Drugs and Biological Products, Pilot National Laboratory for Marine Science and Technology, Qingdao 266235, People's Republic of China.
³ National Natuurhistorisch Museum, 2300 RA Leiden, The Netherlands.
⁴ Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 28789, People's Republic of China.
⁵ College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People's Republic of China.

PMID: 35018782
DOI: 10.1021/acs.jnatprod.1c01103

Abstract

Five new dolabellane diterpenes, clavularinlides A-E (1-5), and four new racemic elemane alkaloids, clavulacylides A-D (7-10), together with one known compound (6), were isolated from the soft coral Clavularia inflata collected in the South China Sea. Their structures were elucidated by 1D and 2D NMR, HRESIMS, calculated ECD, and DP4+ probability analyses. Compounds 1-7 showed anti-inflammatory activity in the zebrafish assay.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents / pharmacology
China
Diterpenes / chemistry*
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Molecular Structure
Monocyclic Sesquiterpenes / chemistry*
Monocyclic Sesquiterpenes / isolation & purification*
Monocyclic Sesquiterpenes / pharmacology
Spectrum Analysis / methods
Zebrafish

Substances

Anti-Inflammatory Agents
Diterpenes
Monocyclic Sesquiterpenes
dolabellane