Diagnostic performance of 18 F-FDG-PET/CT in inflammation of unknown origin: A clinical series of 317 patients

Abstract

Background: Inflammation of unknown origin (IUO) is a challenging situation in internal medicine.

Objectives: To describe the final diagnoses in IUO and assess the helpfulness of ¹⁸ F-fluorodesoxyglucose positron emission tomography with computerized tomography (¹⁸ F-FDG-PET/CT) in the diagnosis strategy.

Results: A total of 317 IUO patients with ¹⁸ F-FDG-PET/CT were enrolled. A diagnosis was reached in 228 patients: noninfectious inflammatory diseases (NIID) (37.5%), infectious diseases (18.6%), malignancies (7.9%), and non-systemic-inflammatory miscellaneous diseases (7.9%). The two leading causes of NIID were polymyalgia rheumatica and giant cell arteritis. ¹⁸ F-FDG-PET/CT results were classified as true positive in 49.8% of patients and contributory in 75.1% of overall IUO patients (after the complete investigation set and a prolonged follow-up). In multivariate analysis, only C-reactive protein minimum level (≥50 mg/L) was associated with the contributory status of ¹⁸ F-FDG-PET/CT.

Conclusion: Within the wide spectrum of IUO underlying diseases, ¹⁸ F-FDG-PET/CT is helpful to make a diagnosis and to eliminate inflammatory diseases. Obese patients constitute a specific group needing further studies.

Keywords: 18F-FDG-PET/CT; PET-CT; fever of unknown origin; giant cell arteritis; inflammation of unknown origin; obesity; polymyalgia rheumatica.