Migration characteristics as a prognostic factor in cerebral sparganosis

Li Feng; Xiao Jiao; Chang Zeng; Charlie W Zhao; Rong Li; Leiyao Zhang; Zhuanyi Yang; Weihua Liao; Dingyang Liu; Bo Xiao; Zhiquan Yang

doi:10.1016/j.ijid.2022.01.005

Migration characteristics as a prognostic factor in cerebral sparganosis

Int J Infect Dis. 2022 Apr:117:28-36. doi: 10.1016/j.ijid.2022.01.005. Epub 2022 Jan 10.

Authors

Li Feng¹, Xiao Jiao², Chang Zeng³, Charlie W Zhao⁴, Rong Li⁵, Leiyao Zhang⁵, Zhuanyi Yang⁶, Weihua Liao², Dingyang Liu⁶, Bo Xiao⁷, Zhiquan Yang⁸

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
² Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
³ Health Management Center, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁴ Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, USA, 06520.
⁵ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
⁶ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
⁷ Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address: xiaobo_xy@126.com.
⁸ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address: y66406914@163.com.

PMID: 35017108
DOI: 10.1016/j.ijid.2022.01.005

Abstract

Objective: To differentiate diagnostic and prognostic factors from the clinical material of patients with cerebral sparganosis in central South China.

Methods: Consecutive patients with cerebral sparganosis from our hospital between 2010 and 2018 were retrospectively enrolled. The clinical manifestations, radiographic features, treatment, and outcomes of these patients were analyzed.

Results: Thirty patients with cerebral sparganosis were included, and foci migration on magnetic resonance imaging was detected in 22 patients, from whom we observed 4 migration modes: interlobar migration (50.0%, 11/22); transmidline migration (27.3%, 6/22); transventricular migration (13.6%, 3/22); and cerebellum-brainstem migration (9.1%, 2/22). The percentage of good outcomes was higher in patients with live worm capture than in those without live worm capture (75.0%, 12/16 vs 33.3%, 2/6). Exposure to preoperative antiparasitic medication was associated with worm migration toward the cortical surface, which led to a higher probability of live worm capture.

Conclusions: We propose 4 modes of sparganosis migration that are correlated with worm capture and neurologic prognosis. We found that exposure to antiparasitic medication was associated with worm migration toward the cortical surface, leading to a higher probability of live worm capture. These observations suggest a novel significance for preoperative medication of cerebral sparganosis.

Keywords: Cerebral sparganosis; Migration modes; Preoperative medication; Surgical outcome.

MeSH terms

Antiparasitic Agents
Humans
Magnetic Resonance Imaging
Prognosis
Retrospective Studies
Sparganosis* / diagnosis
Sparganosis* / surgery

Substances

Antiparasitic Agents