Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals

Sian Faustini; Adrian Shields; Gemma Banham; Nadezhda Wall; Saly Al-Taei; Chloe Tanner; Zahra Ahmed; Elena Efstathiou; Neal Townsend; Margaret Goodall; Tim Plant; Marisol Perez-Toledo; Aleksandra Jasiulewicz; Ruth Price; James McLaughlin; John Farnan; Julie Moore; Louise Robertson; Andrew Nesbit; Grace Curry; Amy Black; Adam Cunningham; Lorraine Harper; Tara Moore; Mark Drayson; Alex Richter

doi:10.1016/j.jinf.2022.01.002

Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals

J Infect. 2022 Apr;84(4):579-613. doi: 10.1016/j.jinf.2022.01.002. Epub 2022 Jan 10.

Authors

Sian Faustini¹, Adrian Shields², Gemma Banham³, Nadezhda Wall⁴, Saly Al-Taei⁵, Chloe Tanner⁶, Zahra Ahmed⁷, Elena Efstathiou⁸, Neal Townsend⁹, Margaret Goodall¹⁰, Tim Plant¹¹, Marisol Perez-Toledo¹², Aleksandra Jasiulewicz¹³, Ruth Price¹⁴, James McLaughlin¹⁵, John Farnan¹⁶, Julie Moore¹⁷, Louise Robertson¹⁸, Andrew Nesbit¹⁹, Grace Curry²⁰, Amy Black²¹, Adam Cunningham²², Lorraine Harper²³, Tara Moore²⁴, Mark Drayson²⁵, Alex Richter²⁶

Affiliations

¹ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: s.e.faustini@bham.ac.uk.
² Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; University Hospitals Birmingham National Health Service (NHS) Foundation Trust, Birmingham, United Kingdom. Electronic address: a.m.shields@bham.ac.uk.
³ Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; University Hospitals Birmingham National Health Service (NHS) Foundation Trust, Birmingham, United Kingdom. Electronic address: emma.banham@nhs.net.
⁴ Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; University Hospitals Birmingham National Health Service (NHS) Foundation Trust, Birmingham, United Kingdom. Electronic address: nadya.wall@nhs.net.
⁵ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: s.al-taei@bham.ac.uk.
⁶ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: c.l.tanner@bham.ac.uk.
⁷ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: a.zahra@bham.ac.uk.
⁸ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: e.efstathiou@bham.ac.uk.
⁹ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: n.j.townsend@bham.ac.uk.
¹⁰ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: dm.goodall@bham.ac.uk.
¹¹ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: tplant.1@bham.ac.uk.
¹² Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: m.perez-toledo@bham.ac.uk.
¹³ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: a.jasiulewicz@bham.ac.uk.
¹⁴ Biomedical Sciences Research Institute, Ulster University, Northern Ireland. Electronic address: rk.price@ulster.ac.uk.
¹⁵ Nanotechnology and Integrated Bioengineering Centre, Ulster University, Northern Ireland. Electronic address: jad.mclaughlin@ulster.ac.uk.
¹⁶ The Group Surgery, 257 North Queen Street, Belfast, Northern, Ireland. Electronic address: john.farnan@doctors.org.uk.
¹⁷ Biomedical Sciences Research Institute, Ulster University, Northern Ireland. Electronic address: Moore-J66@ulster.ac.uk.
¹⁸ Biomedical Sciences Research Institute, Ulster University, Northern Ireland. Electronic address: lrobertson@ulster.ac.uk.
¹⁹ Biomedical Sciences Research Institute, Ulster University, Northern Ireland. Electronic address: a.nesbit@ulster.ac.uk.
²⁰ Biomedical Sciences Research Institute, Ulster University, Northern Ireland. Electronic address: G.Curry@ulster.ac.uk.
²¹ The Group Surgery, 257 North Queen Street, Belfast, Northern, Ireland. Electronic address: AmyBlack@doctors.org.uk.
²² Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: a.f.cunningham@bham.ac.uk.
²³ University Hospitals Birmingham National Health Service (NHS) Foundation Trust, Birmingham, United Kingdom; Institute of Applied Health, University of Birmingham, Birmingham, United Kingdom. Electronic address: lharper@bham.ac.uk.
²⁴ Biomedical Sciences Research Institute, Ulster University, Northern Ireland; Nanotechnology and Integrated Bioengineering Centre, Ulster University, Northern Ireland; Avellino labs USA 1505 Adams Drive Menlo Park, CA 94025 USA. Electronic address: tara.moore@ulster.ac.uk.
²⁵ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: m.t.drayson@bham.ac.uk.
²⁶ Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; University Hospitals Birmingham National Health Service (NHS) Foundation Trust, Birmingham, United Kingdom. Electronic address: a.g.richter@bham.ac.uk.

No abstract available

Keywords: COVID-19; Chronic kidney disease; Cross reactivity; Delta; Haemodialysis; Omicron; SARS-CoV-2; Variants of Concern; antibody response; vaccination.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Vaccines*
COVID-19* / prevention & control
Glycoproteins
Humans
SARS-CoV-2
Spike Glycoprotein, Coronavirus

Substances

Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Vaccines
Glycoproteins
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2

Supplementary concepts

SARS-CoV-2 variants

Publication types

MeSH terms

Substances

Supplementary concepts

Grants and funding