A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer

Chem Commun (Camb). 2022 Feb 1;58(10):1554-1557. doi: 10.1039/d1cc05903c.

Abstract

A homotypic cancer cell membrane camouflaged zeolitic imidazolate framework (ZIF)-based nanoagent with co-loading of two inhibitors was developed, which could suppress the efflux of protons to induce intracellular acidic stress and down-regulate glutamine metabolism to reduce the energy supply. As a compensation, glycometabolism would be upregulated with simultaneous production of large amounts of lactic acid, which could in turn aggravate the acidosis and further realize a synergetic cancer treatment.

MeSH terms

  • Animals
  • Biomimetic Materials / chemistry*
  • Biomimetic Materials / metabolism
  • Biomimetic Materials / pharmacology
  • Biomimetic Materials / therapeutic use
  • Cell Survival / drug effects
  • Enzyme Inhibitors / chemistry
  • Glutamine / metabolism*
  • Humans
  • Imidazoles / chemistry
  • Lactic Acid / metabolism
  • MCF-7 Cells
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy
  • Sulfides / chemistry
  • Thiadiazoles / chemistry
  • Zeolites / chemistry*

Substances

  • Enzyme Inhibitors
  • Imidazoles
  • Sulfides
  • Thiadiazoles
  • bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide
  • Glutamine
  • Zeolites
  • Lactic Acid
  • imidazole