Abstract
A homotypic cancer cell membrane camouflaged zeolitic imidazolate framework (ZIF)-based nanoagent with co-loading of two inhibitors was developed, which could suppress the efflux of protons to induce intracellular acidic stress and down-regulate glutamine metabolism to reduce the energy supply. As a compensation, glycometabolism would be upregulated with simultaneous production of large amounts of lactic acid, which could in turn aggravate the acidosis and further realize a synergetic cancer treatment.
MeSH terms
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Animals
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Biomimetic Materials / chemistry*
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Biomimetic Materials / metabolism
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Biomimetic Materials / pharmacology
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Biomimetic Materials / therapeutic use
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Cell Survival / drug effects
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Enzyme Inhibitors / chemistry
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Glutamine / metabolism*
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Humans
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Imidazoles / chemistry
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Lactic Acid / metabolism
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MCF-7 Cells
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Nanoparticles / chemistry*
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Neoplasms / drug therapy
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Sulfides / chemistry
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Thiadiazoles / chemistry
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Zeolites / chemistry*
Substances
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Enzyme Inhibitors
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Imidazoles
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Sulfides
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Thiadiazoles
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bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide
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Glutamine
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Zeolites
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Lactic Acid
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imidazole