Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the "better" may become the "enemy of the good" in the course of evolution
Cell Death Differ. 2022 Feb;29(2):266-268.
doi: 10.1038/s41418-021-00927-4.
Epub 2022 Jan 10.
1 Université Paris-Saclay, Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Molecular Imaging Research Center (MIRCen), Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France. emmanuel.brouillet@cea.fr.