When stem cells meet COVID-19: recent advances, challenges and future perspectives

Shasha Li; Hecheng Zhu; Ming Zhao; Weidong Liu; Lei Wang; Bin Zhu; Wen Xie; Cong Zhao; Yao Zhou; Caiping Ren; Hui Liu; Xingjun Jiang

doi:10.1186/s13287-021-02683-1

When stem cells meet COVID-19: recent advances, challenges and future perspectives

Stem Cell Res Ther. 2022 Jan 10;13(1):9. doi: 10.1186/s13287-021-02683-1.

Authors

Shasha Li^{1

2}, Hecheng Zhu³, Ming Zhao³, Weidong Liu^{1

2}, Lei Wang^{1

2}, Bin Zhu^{1

2}, Wen Xie^{1

2}, Cong Zhao^{1

2}, Yao Zhou^{1

2}, Caiping Ren^{4

5}, Hui Liu⁶, Xingjun Jiang^{7

8}

Affiliations

¹ Cancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.
² The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, 410008, China.
³ Changsha Kexin Cancer Hospital, Changsha, 410205, China.
⁴ Cancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. rencaiping@csu.edu.cn.
⁵ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medicine, Central South University, Changsha, 410008, China. rencaiping@csu.edu.cn.
⁶ School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. liuhui@wmu.edu.cn.
⁷ Cancer Research Institute, Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. jiangxj@csu.edu.cn.
⁸ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China. jiangxj@csu.edu.cn.

Abstract

Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory coronavirus 2 is currently spreading throughout the world with a high rate of infection and mortality and poses a huge threat to global public health. COVID-19 primarily manifests as hypoxic respiratory failure and acute respiratory distress syndrome, which can lead to multiple organ failure. Despite advances in the supportive care approaches, there is still a lack of clinically effective therapies, and there is an urgent need to develop novel strategies to fight this disease. Currently, stem cell therapy and stem cell-derived organoid models have received extensive attention as a new treatment and research method for COVID-19. Here, we discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.

Keywords: COVID-19; MSCs; Organoid models; SARS-CoV-2; Stem cell threapy.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

COVID-19*
Humans
Pandemics*
Prospective Studies
SARS-CoV-2
Stem Cells

Abstract

Publication types

MeSH terms

Grants and funding