Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

Valerii D Krasikov; Yulia G Santuryan; Irina I Malahova; Alexey G Ivanov; Nikolay I Gorshkov; Evgenii F Panarin

doi:10.3390/polym14010105

Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy

Polymers (Basel). 2021 Dec 28;14(1):105. doi: 10.3390/polym14010105.

Authors

Valerii D Krasikov¹, Yulia G Santuryan¹, Irina I Malahova¹, Alexey G Ivanov¹, Nikolay I Gorshkov¹, Evgenii F Panarin¹

Affiliation

¹ Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia.

Abstract

Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.

Keywords: N-vinylpyrrolidone/N-vinylamine; bladder tumor; inhibition of β-glucuronidase; lactones of D-glucuronic acid; polymer complexes of glucarolactones; water-soluble copolymers.