Natural polyphenol-based nanoengineering of collagen-constructed hemoperfusion adsorbent for the excretion of heavy metals

Meifeng Li; Xiaoling Wang; Guidong Gong; Yi Tang; Yaoyao Zhang; Junling Guo; Xuepin Liao; Bi Shi

doi:10.1016/j.jhazmat.2021.128145

Natural polyphenol-based nanoengineering of collagen-constructed hemoperfusion adsorbent for the excretion of heavy metals

J Hazard Mater. 2022 Apr 15:428:128145. doi: 10.1016/j.jhazmat.2021.128145. Epub 2022 Jan 3.

Authors

Meifeng Li¹, Xiaoling Wang², Guidong Gong², Yi Tang¹, Yaoyao Zhang³, Junling Guo⁴, Xuepin Liao⁵, Bi Shi⁶

Affiliations

¹ Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
² Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
³ Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
⁴ Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610065, China; National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Chengdu, Sichuan 610065, China. Electronic address: junling.guo@scu.edu.cn.
⁵ Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Chengdu, Sichuan 610065, China. Electronic address: xpliao@scu.edu.cn.
⁶ Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610065, China; National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Chengdu, Sichuan 610065, China.

PMID: 35007965
DOI: 10.1016/j.jhazmat.2021.128145

Abstract

Designing a hemoperfusion adsorbent for the excretion therapy of toxic heavy metals still remains a great challenge due to the biosafety risks of non-biological materials and the desired highly efficient removal capacity. Herein, inspired from the homeostasis mechanism of plants, natural polyphenols are integrated with collagen matrix to construct a polyphenol-functionalized collagen-based artificial liver (PAL) for heavy metals excretion and free radicals scavenging therapy. PAL presents high adsorption capacities for Cu²⁺, Pb²⁺, and UO₂²⁺ ions, up to 76.98 μmol g^-1, 106.70 μmol g^-1, and 252.48 μmol g^-1, respectively. Remarkably, PAL possesses a high binding affinity for UO₂²⁺, Pb²⁺, and Cu²⁺ ions even in the complex serum environment with the presence of biologically-relevant ions (e.g., Mg²⁺, Ca²⁺ ions). Low hemolysis ratio (1.77%), high cell viability (> 85%), high plasma recalcification time (17.4 min), and low protein adsorption (1.02 μmol g^-1) indicate outstanding biocompatibility of this material. This natural polyphenol/collagen-based fully bio-derived hemoperfusion adsorbent provides a novel and potentially applicable strategy for constructing a hemoperfusion adsorbent for heavy metal ions excretion therapy with efficiency and biosafety.

Keywords: Artificial liver; Free radicals scavenging; Heavy metals; Hemoperfusion; Polyphenol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Collagen
Hemoperfusion*
Hydrogen-Ion Concentration
Metals, Heavy*
Polyphenols
Water Pollutants, Chemical* / analysis

Substances

Metals, Heavy
Polyphenols
Water Pollutants, Chemical
Collagen