In vitro and in vivo highly effective antibacterial activity of carbon dots-modified TiO2 nanorod arrays on titanium

Dongmei He; Xiangyu Zhang; Xiaohong Yao; Yongqiang Yang

doi:10.1016/j.colsurfb.2022.112318

In vitro and in vivo highly effective antibacterial activity of carbon dots-modified TiO₂ nanorod arrays on titanium

Colloids Surf B Biointerfaces. 2022 Mar:211:112318. doi: 10.1016/j.colsurfb.2022.112318. Epub 2022 Jan 6.

Authors

Dongmei He¹, Xiangyu Zhang², Xiaohong Yao¹, Yongqiang Yang³

Affiliations

¹ Laboratory of Biomaterial Surfaces & Interfaces, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
² Laboratory of Biomaterial Surfaces & Interfaces, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangxiangyu@tyut.edu.cn.
³ Special Equipment Safety Supervision Inspection Institute of Jiangsu Province, National Graphene Products Quality Inspection and Testing Center (Jiangsu), Wuxi 214174, China. Electronic address: yyqyyq_2008@163.com.

PMID: 35007856
DOI: 10.1016/j.colsurfb.2022.112318

Abstract

Light-triggered antibacterial therapy has been proven to be a secure and effective way to treat bacterial infection. Nevertheless, the long-term security of the common photosensitizer remains to be seen in the body. In this work, carbon dots (CDs) with good biocompatibility are incorporated into TiO₂ nanorods to improve the photocatalytic and photothermal ability of titanium implants under the irradiation of visible light (VL) and near-infrared (NIR) light. The C-TiO₂ NR exhibit excellent in vitro and in vivo antimicrobial effect under 660 nm VL and 808 nm NIR light co-irradiation owing to the combined effect of hyperthermia, reactive oxygen species (ROS) and nanorod structure. Besides, C-TiO₂ NR can improve the adhesion and diffusion of bone marrow mesenchymal stem cells (BMSCs).

Keywords: Antibacterial property; Biocompatibility; Carbon dots; Photo-sensitive coating; Titanium.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Carbon
Hyperthermia, Induced*
Nanotubes*
Titanium / chemistry
Titanium / pharmacology

Substances

Anti-Bacterial Agents
titanium dioxide
Carbon
Titanium