Sentinel lymph node biopsy with a handheld cordless magnetic probe following preoperative MR lymphography using superparamagnetic iron oxide for clinically N0 early oral cancer: A feasibility study

Satomi Sugiyama; Toshinori Iwai; Junichi Baba; Senri Oguri; Toshiharu Izumi; Akihiro Kuwahata; Masaki Sekino; Moriaki Kusakabe; Kenji Mitsudo

doi:10.1016/j.jormas.2022.01.003

Sentinel lymph node biopsy with a handheld cordless magnetic probe following preoperative MR lymphography using superparamagnetic iron oxide for clinically N0 early oral cancer: A feasibility study

J Stomatol Oral Maxillofac Surg. 2022 Oct;123(5):521-526. doi: 10.1016/j.jormas.2022.01.003. Epub 2022 Jan 8.

Authors

Satomi Sugiyama¹, Toshinori Iwai², Junichi Baba¹, Senri Oguri¹, Toshiharu Izumi³, Akihiro Kuwahata⁴, Masaki Sekino⁵, Moriaki Kusakabe⁶, Kenji Mitsudo¹

Affiliations

¹ Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
² Department of Oral and Maxillofacial Surgery/Orthodontics, Yokohama City University hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. Electronic address: iwai104oams@yahoo.co.jp.
³ Department of Radiology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
⁴ Department of Electrical Engineering, Tohoku University Graduate School of Engineering, Sendai, Miyagi 980-8579, Japan.
⁵ Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, Tokyo 113-0032, Japan.
⁶ Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-0032, Japan; Department of Medical Device, Matrix Cell Research Institute Inc, Ushiku, Ibaraki 300-1232, Japan.

PMID: 35007780
DOI: 10.1016/j.jormas.2022.01.003

Abstract

Purpose: Radioisotope (RI) tracers are generally used for preoperative mapping of sentinel lymph node (SLN) and intraoperative detection with a portable γ probe. However, the use of RI has several limitations. Therefore, a method without RI is required for the widespread application of SLN biopsy. The purpose of this study was to evaluate the feasibility of SLN biopsy with a handheld cordless magnetic probe following magnetic resonance lymphography (MRL) using superparamagnetic iron oxide (SPIO) and for clinically N0 early oral cancer.

Materials and methods: MRL using SPIO and SLNB with the handheld cordless magnetic probe were performed for 27 patients with clinically N0 early oral cancer.

Results: In all 27 patients (100%), SLNs were detected by MRL, and the total and mean number of SLNs were 73 and 2.7, respectively. All SLNs identified by MRL were detectable using the magnetic probe in all patients.

Conclusions: SLNB with handheld cordless magnetic probe following preoperative SLN mapping by MRL using SPIO is feasible, without RI use, for neck management in cases of clinically N0 early oral cancer.

Keywords: Early oral cancer; Magnetic probe; Magnetic resonance lymphography; Sentinel lymph node; Sentinel lymph node biopsy; Superparamagnetic iron oxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Feasibility Studies
Ferric Compounds
Humans
Lymphography / methods
Magnetic Iron Oxide Nanoparticles
Mouth Neoplasms* / diagnostic imaging
Mouth Neoplasms* / surgery
Sentinel Lymph Node Biopsy* / methods

Substances

Ferric Compounds
ferric oxide