Nickel-Catalyzed Addition of C-C Bonds of Amides to Strained Alkenes: The 1,2-Carboaminocarbonylation Reaction

Yuri Ito; Syun Nakatani; Ryota Shiraki; Takuya Kodama; Mamoru Tobisu

doi:10.1021/jacs.1c09265

Nickel-Catalyzed Addition of C-C Bonds of Amides to Strained Alkenes: The 1,2-Carboaminocarbonylation Reaction

J Am Chem Soc. 2022 Jan 19;144(2):662-666. doi: 10.1021/jacs.1c09265. Epub 2022 Jan 10.

Authors

Yuri Ito¹, Syun Nakatani¹, Ryota Shiraki¹, Takuya Kodama^{1

2}, Mamoru Tobisu^{1

2}

Affiliations

¹ Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
² Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), Osaka University, Suita, Osaka 565-0871, Japan.

PMID: 35005886
DOI: 10.1021/jacs.1c09265

Abstract

C(aryl)-C(═O) bonds of aryl amides can be activated and added across alkenes with the aid of a nickel catalyst. This 1,2-carboaminocarbonylation reaction enables the dicarbofunctionalization of alkenes with an atom economy of 100%.

Publication types

Research Support, Non-U.S. Gov't