Abstract
Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its "always" positive charge. Herein, we developed pH-responsive CPDIMD that executes tumor targeting delivery via protonation of imidazole groups within the acidic tumor microenvironment.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Arginine / chemistry
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Cell Membrane Permeability
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Delayed-Action Preparations / chemistry*
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Disulfides / chemistry*
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Drug Carriers / chemistry*
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Drug Compounding
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Drug Liberation
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Humans
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Hydrogen-Ion Concentration
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Immunoglobulin G / chemistry*
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Immunoglobulin G / pharmacology
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Neoplasms, Experimental
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Polymers / chemistry*
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Tumor Microenvironment
Substances
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Antineoplastic Agents
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Delayed-Action Preparations
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Disulfides
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Drug Carriers
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Immunoglobulin G
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Polymers
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Arginine