In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s

Chem Commun (Camb). 2022 Jan 27;58(9):1314-1317. doi: 10.1039/d1cc06840g.

Abstract

Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its "always" positive charge. Herein, we developed pH-responsive CPDIMD that executes tumor targeting delivery via protonation of imidazole groups within the acidic tumor microenvironment.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Arginine / chemistry
  • Cell Membrane Permeability
  • Delayed-Action Preparations / chemistry*
  • Disulfides / chemistry*
  • Drug Carriers / chemistry*
  • Drug Compounding
  • Drug Liberation
  • Humans
  • Hydrogen-Ion Concentration
  • Immunoglobulin G / chemistry*
  • Immunoglobulin G / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasms, Experimental
  • Polymers / chemistry*
  • Tumor Microenvironment

Substances

  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Disulfides
  • Drug Carriers
  • Immunoglobulin G
  • Polymers
  • Arginine