The pathophysiology of dry age-related macular degeneration (AMD) and specifically geographic atrophy (GA) has been linked to the complement cascade. This cascade is part of the innate immune system and is made up of the classical, alternative, and lectin pathways. The pathways comprise a system of plasma and membrane-associated serum proteins that are activated with identification of a nonself entity. A number of these proteins have been implicated in the development and progression of dry AMD. The three pathways converge at C3 and cascade down through C5, making both of these proteins viable targets for the treatment of dry AMD. In addition, there are a number of complement factors, CFB, CFD, CFH, and CFI, which are potential therapeutic targets as well. Several different complement-directed therapeutics are being studied for the treatment of dry AMD with the hope that one of these approaches will emerge as the first approved treatment for GA.
摘要: 干性年龄相关性黄斑变性 (AMD), 特别是地图样萎缩 (GA) 的病理生理学与补体级联有关。这种级联反应是先天免疫系统的一部分, 由经典, 替代和凝集素途径构成。这些通路包括一个与血浆和膜相关的血清蛋白系统, 该系统在识别非本体时被激活。其中的许多蛋白与干型AMD的发生和发展有关。这3条通路在C3处汇合, 并通过C5级联, 这两种蛋白为治疗干性AMD的可行靶点。此外, 还有一些补体因子, CFB, CFD, CFH和CFI, 也是潜在的治疗靶点。目前有几种不同的补体导向疗法也正在研究中, 以治疗干性AMD, 希望其中一种成为第一种被批准的GA治疗方法。.
© 2021. The Author(s).