Dendrimer nanoplatforms for veterinary medicine applications: A concise overview

Serge Mignani; Xiangyang Shi; João Rodrigues; Helena Tomás; Jean-Pierre Majoral

doi:10.1016/j.drudis.2022.01.001

Dendrimer nanoplatforms for veterinary medicine applications: A concise overview

Drug Discov Today. 2022 May;27(5):1251-1260. doi: 10.1016/j.drudis.2022.01.001. Epub 2022 Jan 6.

Authors

Serge Mignani¹, Xiangyang Shi², João Rodrigues³, Helena Tomás⁴, Jean-Pierre Majoral⁵

Affiliations

¹ Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, Rue des Saints Peres, 75006 Paris, France; CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal. Electronic address: serge.mignani@staff.uma.pt.
² CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China. Electronic address: xshi@dhu.edu.cn.
³ CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal; School of Materials Science and Engineering, Center for Nano Energy Materials, Northwestern Polytechnical University, Xi'an 710072, China. Electronic address: joaoc@staff.uma.pt.
⁴ CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
⁵ Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France; Université Toulouse, 118 Route de Narbonne, 31077 Toulouse Cedex 4, France. Electronic address: majoral@lcc-toulouse.fr.

PMID: 34999213
DOI: 10.1016/j.drudis.2022.01.001

Abstract

Within the nanoparticle (NP) space, dendrimers are becoming increasingly important in the field of nanomedicine, not only to treat human diseases, but also in veterinary medicine, which represents a new therapeutic approach. Major applications include using dendrimers to tackle highly contagious foot-and-mouth disease virus (FMDV) and swine fever virus (SFV) in pigs, FMDV in cattle, hypothermic circulatory arrest (HCA) in dogs, rabies, and H9N2 avian influenza virus in chickens. As we review here, intramuscular (im) subcutaneous (sc), intravenous (iv), and intraperitoneal (ip) routes of administration can be used for the successful application of dendrimers in animals.

Keywords: Dendrimers; Foot and mouth disease; H9N2 avian influenza; Hypothermic circulatory arrest; Nanomedicine; Swine fever; Veterinary medicine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Chickens
Dendrimers*
Dogs
Foot-and-Mouth Disease Virus*
Foot-and-Mouth Disease*
Influenza A Virus, H9N2 Subtype*
Swine

Substances

Dendrimers