Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy

Yang Li; Jianfeng Gao; Shuping Wang; Shijun Li; Xiaowen Hou; Yanna Pan; Jialu Gao; Xue Qiao; Zhiquan Tian; Deliang Chen; Hai Deng; Zixin Deng; Xuechuan Hong; Yuling Xiao

doi:10.1016/j.jconrel.2022.01.005

Organic NIR-II dyes with ultralong circulation persistence for image-guided delivery and therapy

J Control Release. 2022 Feb:342:157-169. doi: 10.1016/j.jconrel.2022.01.005. Epub 2022 Jan 5.

Authors

Yang Li¹, Jianfeng Gao², Shuping Wang³, Shijun Li³, Xiaowen Hou⁴, Yanna Pan⁴, Jialu Gao⁴, Xue Qiao⁵, Zhiquan Tian⁵, Deliang Chen⁶, Hai Deng⁷, Zixin Deng⁸, Xuechuan Hong⁸, Yuling Xiao⁹

Affiliations

¹ State Key Laboratory of Virology, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa 850000, China; Shenzhen Institute of Wuhan University, Shenzhen 518057, China.
² State Key Laboratory of Virology, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; ABSL-III Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan 430071, China.
³ College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.
⁴ State Key Laboratory of Virology, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
⁵ College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa 850000, China.
⁶ Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China.
⁷ Department of Chemistry, University of Aberdeen, Aberdeen, UK.
⁸ State Key Laboratory of Virology, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa 850000, China.
⁹ State Key Laboratory of Virology, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China; Shenzhen Institute of Wuhan University, Shenzhen 518057, China. Electronic address: xiaoyl@whu.edu.cn.

PMID: 34998914
DOI: 10.1016/j.jconrel.2022.01.005

Abstract

Nanocarriers hold great promise for the controlled release of therapeutic payloads to target organs/tissues and extended duration of anticancer agents in the bloodstream. However, limited data on their in vivo pharmacokinetics and delivery process hamper clinical applications. Here we report a series of micellar nanocarriers self-assembled from new-generation thiophenthiadiazole (TTD)-based NIR-II fluorophores HLAnP (n = 1-4) for simultaneous bioimaging and drug delivery. The NIR-II HLA4P nanocarrier displays exceptional non-fouling performance, minimal immunogenicity, ultralong blood half-life, and high tumor accumulation even with different administration routes. When used as a drug carrier, HLA4P with encapsulated doxorubicin (DOX) realized accurate tumor targeting and continuous real-time in vivo NIR-II tracking of drug delivery and therapy, showing a sustained release rate, improved therapeutic effect, and diminished cardiotoxicity as compared to free DOX. This study provides a new perspective on the design of dual-functional NIR-II fluorophores for diagnostic and therapeutic applications.

Keywords: Drug delivery; Fluorescence imaging; Image-guided therapy; Second near-infrared window (NIR-II); Self-assembly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Doxorubicin
Drug Carriers
Drug Delivery Systems
Fluorescent Dyes
Nanoparticles*
Theranostic Nanomedicine* / methods

Substances

Drug Carriers
Fluorescent Dyes
Doxorubicin