Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

Aristine Cheng; Steven M Holland

doi:10.1016/j.jaci.2021.11.016

Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity

J Allergy Clin Immunol. 2022 Jan;149(1):24-28. doi: 10.1016/j.jaci.2021.11.016.

Authors

Aristine Cheng¹, Steven M Holland²

Affiliations

¹ Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md; Division of Infectious Diseases, Department of Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
² Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: smh@nih.gov.

Abstract

Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.

Keywords: Anticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosis.

Publication types

Research Support, N.I.H., Intramural
Review

MeSH terms

Autoantibodies / immunology*
Autoimmunity
Cytokines / immunology*
Humans

Substances

Autoantibodies
Cytokines

Grants and funding

Z01 AI000647/ImNIH/Intramural NIH HHS/United States